Neuroleptics or antipsychotic drugs
Thorazine® , Trilafon®, Zyprexa®, Risperdal®, Geodon®, Seroquel®, Abilify®, and other antipsychotic medications
Psychiatric drug-induced Chronic Brain Impairment (CBI): Implications for longterm treatment with psychiatric medication. International Journal of Risk & Safety in Medicine, 23: 193-200.
Peter R. Breggin, MD
Abstract: Understanding the hazards associated with long-term exposure to psychiatric drugs is very important but rarely emphasized in the scientific literature and clinical practice. Drawing on the scientific literature and clinical experience, the author describes the syndrome of Chronic Brain Impairment (CBM) which can be caused by any trauma to the brain including Traumatic Brain Injury (TBI), electroconvulsive therapy (ECT), and long-term exposure to psychiatric medications. Knowledge of the syndrome should enable clinicians to more easily identify long-term adverse effects caused by psychiatric drugs while enabling researchers to approach the problem with a more comprehensive understanding of the common elements of brain injury as they are manifested after long-term exposure to psychiatric medications. Treatment options are also discussed.
"Intoxication Anosognosia: The Spellbinding Effect of Psychiatric Drugs", Ethical Human Psychology and Psychiatry, 8, 201-215, 2006.ABSTRACT: Why do so many individuals persist in taking psychoactive substances, including psychiatric drugs, after adverse mental and behavioral effects have become severe and even disabling? The author has previously proposed the brain-disabling principle of psychiatric treatment that all somatic psychiatric treatments impair the function of the brain and mind. Intoxication anosognosia (medication spellbinding) is an expression of this druginduced mental disability. Intoxication anosognosia causes the victim to underestimate the degree of drug-induced mental impairment, to deny the harmful role that the drug plays in the personís altered state, and in many cases compel the individual to mistakenly believe that he or she is functioning better. In the extreme, the individual displays out-of-character compulsively destructive behaviors, including violence toward self and others.
Long-term neuroleptic use tied to tardive dykinesia.
"Parallels between Neuroleptic Effects and Lethargic Encephalitis: The Production of Dyskinesias and Cognitive Disorders," Brain and Cognition 23 (1993).
Neuroleptic Malignant Syndrome, Tardive Dyskinesia, Tardive Dystonia, and Tardive Akathisia 01/12/2008
A sample chapter from Dr. Breggin's 1997 book Brain-Disabling Treatments in Psychiatry.
Brain damage, dementia and persistent cognitive dysfunction associated with neuroleptic drugs 01/12/2008